Optical fibers and fiber-optic sensors (FOS) have been attracting attention in the healthcare industry in recent years, leading to a wave of research activity and development of new products. Given their EM immunity, intrinsic safety, small size and weight, autoclave compatibility, and capability to perform multi-point and multi-parameter sensing remotely, fiber-optic-based sensors are ideally suited for a broad variety of applications — invasive and non-invasive — in life sciences, clinical research, medical monitoring, and diagnostics, ranging from laser delivery systems, to disposable blood gas sensors, to intra-aortic pressure probes.